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Creatine Monohydrate

Creatine Monohydrate in Tradeasia


2-[Carbamimidoyl(methyl)amino]acetic acid

Cas Number


HS Code




Basic Info


Colorless crystals or white granular powder

Common Names



25 Kg Bag

Brief Overview

Creatine monohydrate is normally consumed as a food supplement and is normally on an athlete’s shopping list. The main purpose of consuming it is to improve exercise performance and increase muscle strength. Creatine monohydrate enhances growth factor expression, satellite cell number, and intracellular water content. Hence, improve the strength quality and conditioning workout for intense training. In addition, it is also used to treat muscle disorders, such as Parkinson’s disease and heart failure. Creatine monohydrate appears in white powder and is easily soluble in water. This product is commonly used in energy drinks, protein bars,  powders, milkshakes, and dry powdered drink mixes.

Manufacturing Process

The production started by reacting N-methylglycine, sodium N-methylglycinate and  S-methylisothiourea sulfate, with the ratio of 1:5 to 4:1, in mixture of water and ethanol under the temperature of 300C -1400C and pH from 7 to 13. The adjustment of pH of the reaction was done by using an inorganic acid, such as sulfuric acid and hydrochloric acid.

The separation process of the product was conducted and the separated product was washed with water and 95% ethanol. The final step was to dry vaccum the final product under the condition of below 400C and 20 milibar pressure to obtain the creatine-monohydrate. The final form of the product would be a crystal white powder.

Food Industry  

Creatine Monohydrate is used as additive in food such as in health product to provide energy to all cells in the body to gain muscle mass. It is also used as additive in beverage such as in energy drinks.

Pharmaceutical Industry  

Creatine monohydrate is consumed by athletes to improve their strength and enhance their muscle sizes. It is usually produced as supplements and consumed by bodybuilders. Creatine monohydrate is also consumed by people with lower levels of creatine and sufferers of neurodegenerative disease. 

Cosmetics Industry  

Creatine monohydrate is used in cosmetics and personal care products. It improves cell signaling, reduces fine lines and wrinkles, firms skin, refines pores, and evens out skin tone. Creatine monohydrate is mostly used in skin treatments and anti aging treatment products.

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